• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
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  • 优先权
    • 专利摘要:
    Synthesis module (10) for the synthesis of chemical compounds, and in particular radiopharmaceutical compounds, the synthesis module (10) comprising a loading module (20) capable of receiving multiple chemical cassettes (30) comprising reagents and transfer means, the loading module (20) comprising transfer means (32) capable of moving the cassettes (30) from a location on the loading module (20) to a location connected to the module of synthesis (10) on an interface (11) where mechanical means are placed and are able to interact with the transfer means located on the cassette.
    公开号:BE1024751B1
    申请号:E2017/5651
    申请日:2017-09-13
    公开日:2018-06-25
    发明作者:Michel Guyette；Jozef Comor
    申请人:Ion Beam Applications Sa；
    IPC主号:
    专利说明:

    (30) Priority data:
    10/11/2016 EP 16193281.9 (73) Holder (s):
    ION BEAM APPLICATIONS SA 1348, LOUVAIN-LA-NEUVE Belgium (72) Inventor (s):
    GUYETTE Michel
    1348 LOUVAIN-LA-NEUVE
    Belgium
    COMOR Jozef
    1348 LOUVAIN-LA-NEUVE
    Belgium (54) Apparatus for the synthesis of radiopharmaceuticals (57) Synthesis module (10) for the synthesis of chemical compounds, and in particular of radiopharmaceutical compounds, the synthesis module (10) comprising a loading module (20) capable receiving multiple chemical cassettes (30) comprising reagents and transfer means, the loading module (20) comprising transfer means (32) capable of moving the cassettes (30) from a location on the module loading (20) to a location connected to the synthesis module (10) on an interface (11) where mechanical means are placed and are capable of interacting with the transfer means located on the cassette.
    Fig. I
    BELGIAN INVENTION PATENT
    FPS Economy, SMEs, Middle Classes & Energy
    Publication number: 1024751 Deposit number: BE2017 / 5651
    Intellectual Property Office International Classification: B01J 19/00 Issue date: 06/25/2018
    The Minister of the Economy,
    Having regard to the Paris Convention of March 20, 1883 for the Protection of Industrial Property;
    Considering the law of March 28, 1984 on patents for invention, article 22, for patent applications introduced before September 22, 2014;
    Given Title 1 “Patents for invention” of Book XI of the Code of Economic Law, article XI.24, for patent applications introduced from September 22, 2014;
    Having regard to the Royal Decree of 2 December 1986 relating to the request, the issue and the maintenance in force of invention patents, article 28;
    Given the patent application received by the Intellectual Property Office on September 13, 2017.
    Whereas for patent applications falling within the scope of Title 1, Book XI of the Code of Economic Law (hereinafter CDE), in accordance with article XI. 19, §4, paragraph 2, of the CDE, if the patent application has been the subject of a search report mentioning a lack of unity of invention within the meaning of the §ler of article XI.19 cited above and in the event that the applicant does not limit or file a divisional application in accordance with the results of the search report, the granted patent will be limited to the claims for which the search report has been drawn up.
    Stopped :
    First article. - It is issued to
    ION BEAM APPLICATIONS SA, Chemin du Cyclotron 3, 1348 LOUVAIN-LA-NEUVE Belgium;
    represented by
    FRENNET Pierre-Paul, Center Monnet - Avenue Jean Monnet 1, 1348, LOUVAIN-LA-NEUVE;
    a 20-year Belgian invention patent, subject to the payment of the annual fees referred to in article XI.48, §1 of the Code of Economic Law, for: Device for the synthesis of radiopharmaceuticals.
    INVENTOR (S):
    GUYETTE Michel, Ion Beam Applications Chemin du Cyclotron, 1348, LOUVAIN-LA-NEUVE;
    COMOR Jozef, Ion Beam Applications Chemin du Cyclotron, 1348, LOUVAIN-LA-NEUVE;
    PRIORITY (S):
    10/11/2016 EP 16193281.9;
    DIVISION:
    divided from the basic application: filing date of the basic application:
    Article 2. - This patent is granted without prior examination of the patentability of the invention, without guarantee of the merit of the invention or of the accuracy of the description thereof and at the risk and peril of the applicant (s) ( s).
    Brussels, 25/06/2018, By special delegation:
    BE2017 / 5651
    Apparatus for the synthesis of radiopharmaceuticals
    Field of the invention
    The invention relates to a device for synthesizing radiopharmaceuticals from radioactive compounds and / or chemical reagents located on cassettes or on disposable cassettes.
    The invention relates more specifically to a device for synthesizing radiopharmaceuticals, said device being capable of executing multiple cycles to produce radiopharmaceuticals, without human intervention.
    Description of the Prior Art
    In diagnostic procedures, such as Positron Emission Tomography (PET), Monophotonic Emission Tomography (SPECT), and therapeutic applications, radiopharmaceutical or radiochemical compounds are used, which are labeled with radioactive elements , such as ^ C, 1J N, lb O, 10 F, many others to
    Cu,
    I, and of
    Ga, Lu, U Y, ”Zr, for imaging and therapeutic purposes. The synthesis of these radiopharmaceutical compounds is carried out in devices which allow the various chemical compounds located on a cassette to be brought into contact and heated, when applicable, during synthesis reactions.
    During the synthesis process, four major problems must be resolved. The manipulation of compounds.
    first problem concerns the Compounds contain radioactive substances, which can be harmful to humans who manipulate the synthetic apparatus. In order to avoid any risk associated with the handling of radioactive products, the devices are generally placed in a confined and shielded environment. These devices are controlled by
    BE2017 / 5651 automated means, which control the various operations which allow the synthesis, including the steps of reaction, mixing, transfer, heating and purification. Automation of these devices reduces human error and human exposure to radioactivity.
    The second major problem concerns the quality and purity of the synthesized compounds. These products are injected into humans for diagnostic or therapeutic applications. Therefore, in order to avoid any contamination problem or incorrect dosing of the reaction compounds, cassettes containing all the reaction compounds in pre-dosed vials have been developed. These cassettes allow a single cycle to be performed to produce a radiopharmaceutical compound or substance.
    The third major problem in this technical field concerns the half-life of the synthesized products (for example, products containing 18 F, 68 Ga, etc.). In general, radiopharmaceuticals have a short half-life and cannot be stored for later use. It is therefore necessary to produce radiopharmaceutical compounds at regular intervals and to make more efficient use of the device during the day.
    It would be advantageous if syntheses could be carried out successively (consecutive cycles). Compact automatic synthesizers have a single interface between the cassette and the synthesizer. In addition, the cassettes are often disposable, which allows only a limited number of synthesis cycles. Consequently, once a limited number of synthesis cycles have been executed, the human operator must open the confined and shielded environment, remove the cassettes from the device, and add new cassettes in order to resume the production. This can be dangerous, due to the radioactivity that surrounds the synthesis device. In addition, this can lead to human error. Less operators
    BE2017 / 5651 humans intervene during the synthesis process, the lower the probability of making errors or introducing contamination. This problem is currently solved by existing devices in an unsatisfactory manner. A current solution requires more than a single synthesis machine within the limited shielded environment, while the available space is constrained. Another solution is to reuse disposable cassettes designed for a single cycle, which requires a washing procedure, and jeopardizing the overall quality of the final product. Finally, due to the particularly short half-life of some of the isotopes incorporated in radiopharmaceutical compounds, it may be necessary to avoid any loss of time to produce a required product.
    The fourth problem concerns the flexibility of using the synthesis device. Currently, with a single synthesis device, it is not possible to program and synthesize a range of different radiopharmaceutical compounds without human intervention. When different radiopharmaceutical compounds need to be synthesized, and after an initial cycle, an operator must manually add a new, different cassette to the device to synthesize a new product.
    Various devices have been developed in recent years, but not a single one solves the four major problems mentioned above in a satisfactory manner. For example, European Patent No. 1343533 and United States Patent No. 7235216 disclose an apparatus and a cassette which creates a reduced risk of contamination or incorrect dosages. The apparatus may include a lead chamber, intended to reduce risks to the safety of the person performing the synthesis processes. Unfortunately, when multiple cycles are to be performed over a time interval mentioned above are not resolved, cassette on the synthesizer short, the problems
    The loading of the must be executed
    BE2017 / 5651 manually by an operator, which exposes the operator to residual radioactivity when he opens the shielded environment.
    Summary of the invention
    To at least partially solve the problems of the state of the art, an object of the invention is to provide a synthesis apparatus capable of executing a plurality of synthesis cycles in a safe and harmless manner, without any intervention human during the plurality of syntheses. It is an object of the invention to provide an apparatus for synthesizing radioactive products, in particular radiopharmaceuticals, from radioactive elements, which can be used in a safe manner. Once a person has prepared the apparatus for multiple synthesis cycles, the apparatus according to the invention is capable of executing multiple cycles successively without requiring human intervention. Likewise, an object of the present invention is to provide an apparatus which minimizes the risk of contamination of the synthesized products, while ensuring the safety of the persons who handle the synthetic product. While ensuring the execution of multiple consecutive synthesis cycles, the present invention provides the characteristic which consists in synthesizing different products consecutively with the same apparatus, without human intervention between the consecutive cycles.
    Consecutive cycles can produce different products depending on the cassettes that have been loaded on the magazine.
    The invention is defined by the independent claims. The dependent claims define advantageous embodiments.
    According to the invention, an apparatus is provided for manufacturing radiopharmaceuticals from reagents, the apparatus comprising a synthesis device and a loading device on which chemical systems are present under
    BE2017 / 5651 the form of a plurality of cassettes can be mounted, in which the cassettes comprise means for transferring chemical reagents. The synthesis device contains an interface and mechanical means capable of acting on the transfer of the cassettes when the cassettes are connected to the interface. The apparatus is characterized in that it comprises displacement means capable of successively displacing the plurality of cassettes from a storage position to a position connected to the interface, and in that the synthesis device further includes ejection means capable of ejecting a disposable cassette connected to the interface.
    Indeed, with an apparatus according to the invention, the four major problems mentioned above are at least partially resolved. The entire device can be placed in a safe and shielded environment, or the entire device itself can be shielded to prevent any emission of radioactivity outside the synthetic device. The plurality of cycles are carried out inside cassettes which comprise for each cycle the reagents necessary for the synthesis of the desired radiopharmaceutical compounds. No human intervention is required between cycles, leading to safe production of radioactive compounds without any exposure of the operator (s) to harmful radiation.
    Another major advantage of the present invention is that multiple syntheses of the same radiopharmaceutical compound can be performed, when all of the cassettes are of the same type. In addition, it is also possible to perform syntheses of a range of different radiopharmaceutical compounds when the cassettes are of a different type. Consequently, according to the needs of patients for radiopharmaceutical compounds, the apparatus makes it possible to produce different compounds in correlation with these needs. If a number of patients need to receive the same radiopharmaceutical, a sufficient amount can be produced without human intervention once the device is loaded with the cassettes. On the other hand,
    BE2017 / 5651 when a number of patients need to receive different radiopharmaceuticals, a variety of these can be produced without human intervention. It is therefore possible to produce identical or different radioactive compounds without human intervention. With the apparatus according to the invention, the loading of each new cassette onto the synthesis apparatus between synthesis cycles is automatic.
    Preferably, the apparatus according to the invention comprises displacement means comprising transfer means capable of successively transferring the cassettes from the storage position to a loading position located near the interface, and the the apparatus comprises means capable of fixedly connecting the cassettes to the interface.
    According to this preferred embodiment of the invention, the connection of each cassette to the interface located on the synthesis device is fixed, leading to a more reliable device, thus avoiding any bad connection between the cassette and the interface.
    Better still, the apparatus according to the invention comprises displacement means capable of placing a positioning wedge on the secure connection means when the displacement means move a cassette from the storage position to the position loading.
    According to this preferred embodiment of the invention, the interaction between the displacement means and the secure connection means ensure an even more reliable positioning and connection of the cassette.
    BE2017 / 5651
    Brief description of the drawings
    These and other aspects of the invention will be explained in more detail by way of examples and with reference to the accompanying drawings, in which:
    Figure 1 schematically shows an apparatus according to an embodiment of the invention in which the apparatus is loaded with several cassettes and a cassette is connected to the interface;
    Figure 2 schematically shows the apparatus shown in Figure 1 in which the cassettes are all arranged on the loading device;
    Figure 3 schematically shows the apparatus shown in Figure 1 in which placement means are illustrated; Figure 4 schematically shows the apparatus shown in Figure 1 in which the displacement means are illustrated; and Figure 5 schematically shows the apparatus shown in Figure 2 in which the displacement means are illustrated.
    The drawings of the figures are neither drawn to scale nor proportioned. In general, identical or similar components are designated by the same reference numerals in the figures.
    Detailed description of embodiments of the invention
    As illustrated in Figure 1, the apparatus (1) according to the present invention comprises a synthesis device (10) and a loading device (20). The apparatus is capable of producing radiopharmaceuticals from reagents, preferably chemical reagents, when a cassette (30) is placed or fixed on an interface (11) and the apparatus (1) is in operation. The cassette can be a reusable cassette or a disposable cassette.
    BE2017 / 5651
    A cassette (30), also called module, is a removable cassette well known to those skilled in the art, which can be reusable, washable, or preferably disposable after one or more synthesis cycles. In a more preferred embodiment, the cassette is a disposable cassette, and more preferably a disposable disposable cassette. This cassette is generally in the form of support means and may contain chemical reagents, one or more reaction compartments, transfer means between the chemical reagents and the reaction compartments. This cassette is described for example in document EP 1343533.
    The cassette (30), on which transfer, reaction and purification functions are performed and the chemical reagents and reaction compartments are arranged, is
    destined to be associated with device of synthesis (10) on The interface (11) · The interface (11) can be a fixed module located on the device of synthesis (10), and in which one plurality means
    mechanical are arranged, these mechanical means being capable of cooperating with the transfer means present on the disposable cassette (30) so as to allow the transfer of the reagents from the different reagents to the different reaction compartments. The various operations for synthesizing pharmaceutical products, including the actuation of these mechanical means, are controlled by means of an automaton. In other words, the apparatus (1), and more specifically the synthesis device (10), can be connected to an automaton which controls the various operations which allow the synthesis to be carried out, comprising reaction steps and of heating; which are associated with the transfer of reagents. This is also well known to those skilled in the art, and is described in document EP 1343533.
    BE2017 / 5651
    As illustrated in Figure 1, the loading device (20) can be mounted on the synthesis device (10). Note however that the loading device (20) can be mounted on other parts, in addition to the synthesis device (10), for example on one side of the synthesis device.
    In another embodiment of the invention, the charging device (20) can even be placed outside the shielded environment. In a preferred embodiment, the loading device (20) is mounted on top of the synthesis device (10). The synthesis device (10) could be self-shielded or placed in a shielded environment (also called a hot cell). In an alternative embodiment, the apparatus (1) comprising the synthesis device (10) and the loading device (20) is self-shielded (that is to say surrounded by lead plates or enclosed in inside a lead shield). In other words, the synthesis device or the entire apparatus is confined within a shield which reduces the emission of radiation outside the shielded synthesis device or the shielded device.
    A plurality of cassettes (30) can be mounted on the loading device (20). As illustrated in Figure 1, the plurality of cassettes can be mounted on a rack (60) in a linear arrangement, the cassettes being parallel to each other. The rack can be in the form of two horizontal strips or bars on which the cassettes are placed. It should be noted that other arrangements can be envisaged. For example, the plurality of cassettes could be arranged on a carousel. By plurality of cassettes, it should be understood that at least two cassettes can be placed on the loading device, in a more preferred embodiment, at least three cassettes can be placed on the loading device and, in a mode of more preferred embodiment, at least four cassettes can be arranged on the loading device (20). Of course, the charging device (20) can
    BE2017 / 5651 have a different shape. For example, the loading device may be a circular platform in which the cassettes are not parallel to each other, but are mounted on the circular platform like shelves.
    It will also be noted that it is not necessary for the plurality of cassettes to be identical with regard to their content of chemical reagents and / or of their reaction compartments. The outer edge of the plurality of cassettes (30) must of course have the same shape so as to cooperate with the loading device (20), but the content of the reagents may be different, for example when a variety of radiopharmaceutical compounds have to be produced. Of course, the plurality of cassettes (30) could be identical with regard to their content when a single radiopharmaceutical compound must be produced by the synthesis device (10).
    When a person prepares the apparatus according to the invention for multiple cycles to synthesize different products, he simply needs to place / arrange each cassette on the loading device, in the order provided for synthesizing the different radiopharmaceutical products. Once the cassettes are placed on the loading device (20), no direct human intervention is necessary for loading, moving, connecting or ejecting each cassette. When a cassette is placed on the loading device (20), the cassette is defined as being in its stacking or storage position. This is illustrated in Figure 2.
    The apparatus (1) comprises means capable of successively moving the plurality of cassettes (30) from a storage position to a position connected to the interface (11). By displacement, it is necessary to understand the displacement of each cassette from a position in which the cassette is placed on the loading device.
    BE2017 / 5651 (20) in its storage position, up to the position in which the cassette is operatively connected to the synthesis device (10) by means of the interface (11) (the connected position). The functional connection between the synthesis device (10) and a cassette is illustrated in Figure 1. The movement from a storage position to a connected position on the interface (11) is carried out by at least displacement means (32). These displacement means can interact with an edge of the cassette, and move the latter from its storage position to the connected position. The function of the displacement means (32) consists in successively moving each cassette from its storage position (illustrated in FIG. 2) to its position connected with the interface (11), illustrated in FIG. 1. The displacement means (32) may be present on the loading device (20) or on the synthesis device (10). In a preferred embodiment, the displacement means are located on the loading device (20).
    A variety of means of movement (32) can be envisaged. For example, the displacement means can be a piston or a hydraulic cylinder controlled by an automaton. When the piston or a hydraulic cylinder is activated, it moves the cassette from its storage position to the connected position. Note that the movement of movement can be any type of movement, such as a rotation of the cassette, a translation of the cassettes, a plurality of translations of the cassettes or a combination between rotation and translation.
    The displacement means can be present on the synthesis device (10) or on the loading device (20). In a preferred embodiment, the displacement means are located on the loading device (20), as illustrated for example in FIG. 4.
    BE2017 / 5651
    When the cassette is in its connected position, as illustrated in Figure 1, the synthesis of radiopharmaceuticals can begin. The synthesis device (10) interacts with the cassette connected to the interface (11) using mechanical means, as explained above. The total interaction between the synthesis device (20) and the transfer means on the cassette can be controlled by an automaton.
    When the synthesis is complete, the cassette connected to the interface (11) is ejected. To this end, the synthesis device (10) comprises means capable of ejecting the cassette connected to the interface (11). This is illustrated in Figure 5.
    As illustrated, ejection means (12) are located near the interface (11). When the synthesis cycle is finished, the ejection means are activated and the cassette is removed from the interface, and can be thrown into an armored container. The ejection means can for example be a piston or a hydraulic cylinder which, when actuated, makes it possible to depend on or unhook the cassette from the interface (11). The cassette can then fall into an armored container. Once the cassette has been ejected, the ejection means can return to their original position.
    Once the cassette used for a synthesis cycle has been ejected from the interface (11), another cassette located on the loading device (20) in its storage position can be moved from this position to the connected position of the interface (11).
    Consequently, as long as a cassette is present on the loading device (20), a new synthesis cycle can be executed after the ejection of the previous cassette, without any human intervention.
    BE2017 / 5651
    In a preferred embodiment of the invention, the displacement means (32) comprise transfer means (320) and connection means (321). In this embodiment, the movement of the cassette from its storage position to the connected position comprises two movements. The first movement is the movement of the cassette from its storage position, illustrated in Figure 2, to a loading position, illustrated in Figure 4. The loading position is a position near the interface (11) but where the cassette is not connected to the interface (11).
    This movement is achieved by the transfer means (320). The transfer means can, for example, be a piston or a hydraulic cylinder. When the piston or hydraulic cylinder is activated, it moves the cassette from its loading position to the connected position. Note that this displacement can be any type of displacement, such as a rotation of the cassette, a translation of the cassettes, a plurality of translations of the cassettes or a combination between rotation and translation. According to this preferred embodiment, the second movement is the movement of the cassette from the loading position to the connected position, as illustrated in Figure 2 and Figure 1. This movement is achieved by the connection means. It allows to carefully fix the connection between the cassette and the interface (11), which reduces the risk of incorrect connection between the cassette and the interface, so as to avoid damage to the cassette and / or the interface ( that is, the mechanical means located on the interface) to ensure that the synthesis process will be executed efficiently. For example, this narrow and precise movement of the connection means which ensure correct interaction between the cassette and the interface (11) makes it possible to avoid any leakage of the reagents after the connection.
    The connection means may, for example, be a piston or a hydraulic cylinder which moves the cassette from the
    BE2017 / 5651 connected position, like this
    In one embodiment of the loading position is a single movement of ensures easy connection and cassettes.
    loading position up to is shown in Figure 4. Preferred, moving from to the connected translation position. This precise single movement between the interface (11) and
    In a preferred embodiment of the invention, the connection means are located on the synthesis device (20), and in a still preferred embodiment, near the interface (11). In a more preferred embodiment, the ejection means and the connection means are capable of ejecting a cassette when it is connected to the interface (11) and are capable of fixedly connecting the cassette when it is in in the loading position. These means can be a piston or a hydraulic cylinder. In a more preferred embodiment, these same means are a double action hydraulic cylinder.
    In a preferred embodiment of the invention, the displacement means (32) also comprise placement means (322). This is for example illustrated in FIG. 3. The placement means (322) are capable of successively placing the cassettes from a stacking position in their storage position, both potentially located on the loading device ( 20). In the most general embodiment of the invention, these two positions can be the same. In this particular embodiment, each cassette is successively moved from its stacking position, that is to say the position in which it was placed on the loading device (20) before the apparatus begins to launch a plurality of syntheses, up to the storage position, already defined previously, that is to say the position in which the cassette is moved through the connected position. For example, as shown in Figure 2, the cassettes are placed parallel to each other on
    BE2017 / 5651 a rack. The first cassette (301) is in its storage position, while the other three cassettes (302, 303, 304) are in their stacking position. Once the first cassette (301) is moved from the storage position to the connected position, the second cassette (302) moves from its stacking position to the storage position. This displacement can occur during the movement of movement of the first cassette, but it can also occur after the first cassette (301) has been ejected by the ejection means (12), as illustrated in Figure 4 As illustrated in Figures 1 and 4, the different cassettes can have a plurality of stacking positions when they are moved progressively on the rack through the storage position.
    The placement means (322) which allow the displacement of the cassette from a storage position to a stacking position can for example be a piston or a hydraulic cylinder connected to the rack or to each cassette, for example using pushing means, such as a mechanical finger, or gripping means, such as a jaw. In a preferred embodiment of the invention, the placement means (322) are capable of linearly moving the cassettes from their stacking position to their storage position. For example, the loading device (20) may include a rail on which the cassettes are placed in their storage position. The rail is gradually moved through the stacking position by the placement means, pushing the disposable cassettes from their stacking position to their storage position.
    In a preferred embodiment of the invention, the displacement means are capable of linearly moving the cassette from its storage position to its connected position. Alternatively, when the means of displacement
    BE2017 / 5651 include connecting means, the moving means are capable of linearly moving the cassette from its storage position to the loading position, and the connecting means may be able to move linearly the cassette from the loading position to the connected position. These linear movements are simple movements, which do not require any complex arrangement between the different means which are capable of moving the cassette from one place to another. They provide a more robust device, and allow greater precision of movement. For example, the displacement means, and the connection means when they are present, can both be a piston or a hydraulic cylinder, preferably actuated by an automaton which cooperates with a computer.
    In a preferred embodiment of the invention, the displacement means (32) are further capable of placing a positioning wedge (15) on the connection means when the displacement means (32) move a cassette from its storage position to the loading position. This embodiment requires that the connection means (321) be present. The wedge allows the fine positioning of part of the connection means (321) which will be in interaction with the cassette. The interaction between the cassette and the connection means (321) is therefore safer and easier. It ensures that the connection movement operated by the connection means is a fair and precise movement, which allows good interaction between the cassette and the interface (11) after the connection movement. This embodiment is for example illustrated in Figure 5. As can be seen, the displacement means (32) and the connection means (321) are both hydraulic cylinders. The connection means (321) comprise a first movable part which is capable of interacting with the cassette, and a second fixed part. The first part and the second part are connected by the hydraulic cylinder which allows the displacement of the first part.
    BE2017 / 5651
    When the displacement means move the cassette to the loading position, they also place the positioning wedge (15) between the first part and the second part. The connection means can then be removed, that is to say that the hydraulic cylinder is actuated to move the first part through the second part. The wedge is sized to allow the first part to be placed exactly where it is capable of interacting properly with the cassette once it has reached the loading position. When the cassette is in the loading position, the connection means interact with the cassette in a safe manner, preventing damage to the cassette. The displacement means can then be actuated rearward in order to remove the wedge from the connection means. Finally, the connection means can be actuated to connect the cassette to the interface (11).
    In a more preferred embodiment, the connection means can comprise additional interaction means capable of interacting with the positioning means located on the cassette. These interaction means allow improved interaction between the cassettes and the connection means (321), further improving the precision of the movement of the cassette from the loading position to the connected position. The positioning means can for example be a groove capable of interacting with a rod located on the disposable cassette. Of course, a groove can be formed on the cassette while the positioning means are a rod. Similar means are also envisaged by the present invention.
    In a preferred embodiment of the invention, the different means for moving the cassette from any position to another position are actuated by an automaton which cooperates with a computer. In other words, the different means of movement are connected to an automaton which
    BE2017 / 5651 cooperates with a computer, said automaton being capable of controlling the operations which allow the movement of the plurality of cassettes. This allows automatic activation of the different means so as to ensure a correct actuation sequence for each of the means for successively moving each cassette located on the loading device at the interface, and for ejecting the latter after each synthesis cycle. . The computer can of course include dedicated software for programming these actuation sequences.
    In another aspect of the invention, the apparatus further comprises a plurality of cassettes. Each cassette comprises at least one shoulder capable of fitting into grooves located on the loading device (20), the placement means (322) being capable of moving at least one cassette through the grooves. This ensures correct movement of the cassette from a stacking position to the storage position or to another stacking position.
    The cassette can also include dedicated means capable of interacting selectively or universally with the different displacement means (the translation means, the connection means, the placement means, the ejection means). By selective interaction, it should be understood that a plurality of different means each capable of cooperating with only one means of movement are located on the cassette; whereas by universal interaction, it should be understood that only one means located on the cassette is capable of cooperating with all the means of movement. For example, the displacement means can comprise grooves and the cassette can comprise a rod. The different displacement means are all capable of moving the cassette through the groove to move the latter from one location to another location through its interaction with the rod located on the cassette. Other means can also be considered by the present invention, such as a plurality of gripping means.
    BE2017 / 5651
    In a preferred embodiment of the invention, the displacement means (32) further comprise pushing means, such as a mechanical finger, or gripping means, such as a
    jaw, means of hanging or means grip capable to seize, d 'to hook or to grab a cassette disposable. These means are capable of hang out or to push the cassette through the position connected or the position of
    loading when the displacement means are actuated. This allows easier movement of the cassette. For example, when the loading device (20) is located at the top of the synthesis device, the gripping means can help to correctly move the disposable cassette by transmitting a greater displacement force to the disposable cassette. In a preferred embodiment, these means are pushing means, such as a finger, which push the disposable cassette downwards through its connection position.
    The present invention has been described in terms of specific embodiments, which are illustrative of the invention and should not be interpreted as being limiting. More generally, a person skilled in the art will appreciate that the present invention is not limited by what has been particularly shown and / or described here. The reference numerals in the claims do not limit their protective scope. The use of verbs to understand, include, be composed of or any other variant, as well as their respective conjugations, does not exclude the presence of elements other than those indicated. The use of articles one, one or the / the before an element does not exclude the presence of a plurality of these elements.
    The invention can also be described as follows: a synthesis module for the synthesis of chemical compounds, and in particular of radiopharmaceutical compounds, said synthesis module comprising a loading module capable of receiving a plurality of chemical cassettes comprising reagents and
    BE2017 / 5651 transfer means, the loading module comprising transfer means capable of moving the cassettes from a place on the loading module to a place connected to the synthesis module, where mechanical means are arranged and are capable of interacting with the transfer means located on the cassette or on the synthesis device.
    BE2017 / 5651
    权利要求:
    Claims (14)
    [1]
    Claims
    1. Apparatus (1) for manufacturing radiopharmaceuticals from reagents, the apparatus (1) comprising a synthesis device (10) and a loading device (20) on which chemical systems are in the form of a plurality of cassettes (30) comprising the reagents can be mounted, said cassettes (30) comprising means for transferring the chemical reagents, the synthesis device (1) comprising an interface (11) and mechanical means capable of acting on the cassette transfer means when the cassettes (30) are connected to the interface (11), characterized in that the apparatus (1) comprises displacement means (32) capable of successively displacing the plurality of cassettes (30 ) from a storage position to a position connected to the interface (11), and in that the synthesis device (10) further comprises ejection means (12) capable of ejecting a connected cassette at the interface (11).
    [2]
    2. Apparatus (1) according to claim 1, characterized in that the displacement means (32) are located at least partially on the loading device (20).
    [3]
    3. Apparatus (1) according to claim 1 or 2, characterized in that the displacement means (32) comprise transfer means (320) capable of successively transferring the cassettes (30) from the storage position to in a loading position located on or near the interface (11), and in that the device (1) comprises connection means (321) capable of fixedly connecting the cassettes (30) to the interface ( 11).
    [4]
    4. Apparatus (1) according to claim 3, characterized in that the connection means (321) are located on the synthesis device (10).
    BE2017 / 5651
    [5]
    5. Apparatus (1) according to any one of the preceding claims, characterized in that the loading device (20) comprises placement means (322) capable of successively placing the cassettes (30) from a position d 'stacking up to the storage position.
    [6]
    6. Apparatus (1) according to claim 5, characterized in that the placement means (322) are capable of linearly moving the cassettes (30) from their stacking position to the storage position.
    [7]
    7. Apparatus (1) according to any one of the preceding claims, characterized in that the displacement means (32) are capable of linearly displacing the cassettes (30) from the storage position to the position connected, and / or from the storage position to the loading position.
    [8]
    8. Apparatus (1) according to claim 3, characterized in that the displacement means (32) are capable of placing a positioning wedge (15) on the connection means (321) when the displacement means (321) move a cassette from the storage position to the loading position.
    [9]
    9. Apparatus (1) according to claim 3, characterized in that the ejection means (11) and the connection means (321) are the same means.
    [10]
    10. Apparatus (1) according to claim 9, characterized in that the connection means (321) comprise interaction means capable of interacting with positioning means located on the cassettes (30) for positioning the cassettes (30 ).
    BE2017 / 5651
    [11]
    11. Apparatus (1) according to any one of the preceding claims, characterized in that the synthesis device (10) is self-shielded or located in a shielded environment, and better still in that the synthesis device (10) and the charging device (20) are self-shielded or located in a shielded environment.
    [12]
    12. Apparatus (1) according to any one of the preceding claims, characterized in that the displacement means (32), the ejection means (12), and when the transfer means (320) are present, the connection means (321) and the placement means (322), are connected to an automaton which cooperates with a computer, said automaton being capable of controlling the operations which allow movement, placement, transfer, connection and / or ejecting the plurality of cassettes (30).
    [13]
    13. Apparatus (1) according to claim 5, the apparatus further comprising the cassettes (30), and characterized in that each cassette comprises at least one shoulder capable of fitting into grooves located on the loading device ( 20) and / or the synthesis device (10), the placement means (322) being able to move the cassettes by moving them through the grooves.
    [14]
    14. Apparatus according to any one of the preceding claims, characterized in that the displacement means (32) further comprise pushing means or gripping means capable of guiding or gripping a cassette, in which the pushing means or the gripping means are capable of moving a cassette through the connected position or the loading position when the moving means are actuated.
    BE2017 / 5651
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    同族专利:
    公开号 | 公开日
    BE1024751A1|2018-06-20|
    EP3308852A1|2018-04-18|
    JP2018072325A|2018-05-10|
    US20180099261A1|2018-04-12|
    JP6953243B2|2021-10-27|
    CN209405298U|2019-09-20|
    EP3308852B1|2020-12-02|
    KR20180040089A|2018-04-19|
    US10919019B2|2021-02-16|
    CN107913413A|2018-04-17|
    引用文献:
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    EP1216715A1|2000-12-22|2002-06-26|Ion Beam Applications S.A.|Synthesing device von radiopharmaceuticals|
    US7235216B2|2005-05-01|2007-06-26|Iba Molecular North America, Inc.|Apparatus and method for producing radiopharmaceuticals|
    US7954624B2|2006-05-16|2011-06-07|Rorze Corporation|Shuttle type conveying device, microplate feeding and collecting device, pickup device for microplate, cassette for microplate, and shelf for containing microplate|
    ITRM20110223A1|2011-04-28|2012-10-29|Seventeen Srl|AUTOMATIC APPARATUS FOR THE SYNTHESIS OF PEPTIDIC-BASED RADIOPHARMACEUTICALS FOR DIAGNOSTIC AND / OR THERAPEUTIC USE.|
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    WO2014160799A1|2013-03-26|2014-10-02|The Regents Of The University Of California|An automated, multi-pot high-pressure radio-synthesizer for production of pet tracers|
    JP2016528000A|2013-08-22|2016-09-15|サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング|Use of assemblies and damping members for drug delivery devices|
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    法律状态:
    2018-08-29| FG| Patent granted|Effective date: 20180625 |
    优先权:
    申请号 | 申请日 | 专利标题
    EP16193281.9|2016-10-11|
    EP16193281.9A|EP3308852B1|2016-10-11|2016-10-11|Apparatus for the synthesis of radiopharmaceutical products|
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